AhR pathway activation prevents food allergy in mice partly by preserving CD25-positive Tregs in the thymus
نویسندگان
چکیده
Background Food allergy is an increasing health problem. We and others have shown that the intensity of food allergic reactions can be regulated by regulatory T (Treg) cells. In addition, others have shown that activation of the aryl hydrocarbon receptor (AhR) is able to induce Treg cells. Here, we investigated whether activation of the AhR could suppress food allergic responses through the induction of Treg cells in a mouse peanut allergy model.
منابع مشابه
CD4+CD25+ regulatory T cells specific for a thymus-expressed antigen prevent the development of anaphylaxis to self.
A role for CD4(+)CD25(+) regulatory T cells (Tregs) in the control of allergic diseases has been postulated. We developed a mouse model in which anaphylaxis is induced in SJL mice by immunization and challenge with the fragment of self myelin proteolipid protein (PLP)(139-151), that is not expressed in the thymus, but not with fragment 178-191 of the same protein, that is expressed in the thymu...
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